Medicinal plants have curative properties due to the presence of various complex chemical constituents of different composition, which are found as secondary plant metabolites in one or more parts of these plants. Indian medicinal plants used in the Ayurvedic traditional system to treat diabetes are a valuable source of novel anti-diabetic agents. Pancreatic a-amylase inhibitors offer an effective strategy to lower the levels of post-prandial hyperglycemia via control of starch breakdown. In this study, Five Indian medicinal plants with known hypoglycemic properties were subjected to sequential solvent extraction and tested for a-amylase inhibition, in order to assess and evaluate their inhibitory potential on a Amylase. Polyherbal formulation consists of aqueous extract of different parts of Gymnema salvestre, Tinospora cordifolia and Lawsonia inermis which showed synergistic hypoglycemic action.
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